Nobivac Lepto 4 Vaccine (L4)

You may have heard of a new vaccine on the market, the Nobivac Lepto 4 vaccine produced by MSD
Animal Health, we have put together this information sheet to help you understand what it all

What is leptospirosis?

Leptospirosis is a bacterial disease that can lead to severe liver and kidney disease in dogs. It is
spread via the urine of infected dogs, in addition to other mammals like rats and mice. The bacteria
enters the body via mucous membranes, broken skin and the ingestion of infected material. The
disease is a zoonosis which means it can be spread from animals to humans or humans to animals, in
humans the disease is known as Weil’s disease. There are a number of different types of Leptospira.


What is in our standard lepto vaccine?

The vaccination we use vaccinates against the two most common serogroups (types) of lepto:

  • Leptospira canicola
  • Leptospira icterohaemorrhagiae

What is in Lepto 4?

The new lepto 4 vaccine contains the same two serogroups as our current vaccine but also provides
some protection for two other serogroups: Australis and Grippotyphosa.


Our position

Currently we have decided to not start routinely using the new vaccination for the following reasons;

  • There is limited evidence to suggest the 2 new serogroups in the new vaccine are of
    significant prevalence in the UK, a lot of the data has been obtained from Europe.
  • The time for the primary vaccination course is much longer, with the new vaccine it is
    recommend that the first vaccine should not be administered until 9 weeks of age and the
    second one 4 weeks after. This means puppies are missing out on essential socialisation time.
  • Also immunity is not active for 3 weeks after the second vaccine compared to 1 week with
    our current protocol meaning you have to wait longer to take your puppy out.
  • Lepto 4 is not compatible with our other main vaccine; by changing to a type that is
    compatible we would not be including protection against parainfluenza virus, a common
    cause of kennel cough.

If you have any queries or questions in regard to the new vaccine or our vaccine protocol then please do contact us. If you request the new vaccine we will happily vaccinate your dog with it but you will have to give us some notice to order it in for you.

We endeavour to keep up to date with any new evidence as is it appears and will adapt our vaccination protocol as necessary in the future.

Lepto 4 Vaccination Client Information
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